Abstract
Background
Measurement method of serological anti-H. pylori antibody test was changed from Enzyme immune assay (EIA) to Latex agglutination turbidity (LA) recently. We evaluated the problem related to the change of measurement method in follow-up patients.
Subjects and Methods
1,345 patients who were conducted serological H. pylori test using LA method from Sept.2015 to March 2016. We compared diagnosis of H. pylori infection using H. pylori antibody between LA method and EIA method in the same patients. The patients were conducted serological H. pylori test using EIA method previously. The cut-off titer of serological H. pylori test was 10 U/mL in LA and EIA. We also checked H. pylori infection using Endoscopic and X-ray finding or past history of H. pylori eradication.
Result
The coincidence rate of H. pylori infection between LA method and EIA method was 92.7%.
But, the coincidence rate was increased 95.3% excluding patients who were successfully eradicated after the previous EIA positive.
But, we checked EIA re-examination in thirteen LA positive patients who had normal finding in gastroscopy and no history of eradication. All patients were negative.
Conclusion
It is important that diagnosis of H. pylori infection should be conducted using not only anti-H. pylori antibody but also other H. pylori examination (ex. urea breath test),endoscopic finding and past history of H. pylori eradication.
