Abstract
The performance of coagulation testing including fibrinogen assay is determined by a combination of reagents and instruments. Almost all coagulation tests are automated using commercially-produced reagents and automated analyzer based on the clotting principle, although the diversity of the combination results in high variation of test results.
We analyzed our results of external quality surveillance in past 10 years, high variation of the fibrinogen assay was observed. Thus, we tried to produce a reference material for the assay and studied if the use of the material could help to improve the high variation.
However, the material was not be able to improve the variation. We, therefore, concluded that current high variation of fibrinogen assay was not caused by not only diversity of reagents but also that of coagulation test analyzers.
