Abstract
Objectives The aim of the present study was to investigate the relationship between serum uric acid (UA) and various factors of the metabolic syndrome based on insulin resistance in Japanese females working abroad.
Design and Setting and Participants 695 Japanese adult females working abroad were divided to age-matched three groups according to serum UA; 284 subjects in the low levels group: [L-group] (UA<4.0 mg/dl), 302 subjects in the middle levels group: [M-group] (4.0 mg/dl≤UA<5.0 mg/dl) and 109 subjects in the high levels group: [H-group] (UA≥5.0 mg/ dl), respectively.
Main Outcome Measures and Results The levels of systolic blood pressure (S-BP), diastolic (D-) BP, fasting plasma glucose (FPG), fasting plasma insulin (FIRI) and insulin resistance (HOMA-IR) in the [H] were significantly higher than those in the [L] and the [M]; HOMA-IR: 1.27 ([L]: p<0.001), 1.39 ([M]: p<0.001), 1.54 ([H]), respectively. Furthermore, the levels of pancreas-β function (HOMA- β) and plasma total cholesterol (T-cholesterol), triglyceride (TG), aspartate transaminase (AST), alanine transferase (ALT) and γ-glutamyl-transpeptidase (γ-GPT) in the [L] were significantly lower than those in the other groups. Serum UA levels were a significantly positive correlation with HOMA-IR, T-chol, TG, S-BP, D-BP, ALT, AST, ALT, γ-GPT, FPG, FIRI, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), weekly physical activity and weekly consumption of alcohol values in all subjects.
Conclusion Serum UA was important precursor for the insulin resistance in adult females working abroad.
