Abstract
Mortality from coronavirus disease 2019 (COVID-19) has decreased since the special approval of therapeutic agents and widespread implementation of vaccination. However, there are only a few reports on the impact of therapeutic agents and vaccination on the clinical outcomes of patients with COVID-19 in community hospitals. Therefore, we conducted a retrospective survey of 90 patients with COVID-19 (including 72 patients receiving dialysis) hospitalized in a single community hospital to analyze their clinical outcomes and prognostic factors. No differences in the frequency of dialysis, diabetes mellitus, malignancy, or smoking history were observed between the survival ( n = 79) and non-survival groups ( n = 11). The percentage of people aged over 75 years, steroid usage, and the levels of C-reactive protein, D-dimer, and interferon-λ3 were significantly higher in the non-survival group than in the survival group, whereas the body mass index was lower in the non-survival group. However, the rate of vaccination and treatment with remdesivir and/or therapeutic antibodies was significantly higher in the survival group. These results suggest that vaccination and treatment with remdesivir and/or neutralizing antibodies contributes to improvement of clinical outcome of patients with COVID-19.
https://ror.org/02a2vbq68 
