Journal of Hard Tissue Biology
Online ISSN : 1880-828X
Print ISSN : 1341-7649
ISSN-L : 1341-7649
International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005
The Mechanism of Bone Resorption Induced by Epiregulin, a Member of EGF Family
Tatsuro MiyaharaTerutaka KatohHiroshi OchiaiNobuko ImanishiEiji SugiyamaSumiyo ItoMitsunori AonoYasutaro MikamiTsutomu SakumaNobuo NemotoToshi Komurasaki
著者情報
ジャーナル フリー

2005 年 14 巻 2 号 p. 277-278

詳細
抄録
We investigated the effect of epiregulin (EPR) and EGF on the bone resorption using mice bones and cells. Both EPR and EGF enhanced bone resorption in 45Ca-prelabeled parietal bone without affecting osteoclast differentiation. These growth factors also enhanced the pit formation by femur-derived osteoclastrich fraction without increasing the number of the osteoclasts in a NS-398 (a COX-2 inhibitor)- sensitive manner. Furthermore, mature osteoclasts, differentiated from RANKL-stimulated RAW264.7 cells, induced pit formation with a longer time of EPR in a gefitinib (an EGFR tyrosinekinase inhibitor)-sensitive manner. These findings suggest that both EPR and EGF acted on osteoblasts to enhance bone resorption indirectly. In addition, EPR is suggested to have a direct stimulating pathway through the activation of EGFR on mature osteoclasts leading to bone resorption.
著者関連情報
© 2005 by The Hard Tissue Biology Network Association(JHTBNet)
前の記事 次の記事
feedback
Top