Abstract
Ozone is a potent oxidative gas, and its bactericidal effect is being applied to various fields include oral. However, the half-life of ozone is extremely short for achieving sufficient disinfection or effectively exerting a bactericidal effect on cells. We focused on the newly developed ozone gel capable of maintaining the ozone effect for a long time. The purpose of this study was to investigate the safety evaluation of ozone gel on animal practice. These finding demonstrated that applications of ozone gel was considered non toxic to the skin and mucous membrane. These results suggest that the ozone gel can be used widely and is clinically useful as well.
