抄録
The bactericidal potency of ozone was examined for exploring the potential of dental application of ozone gel. Treatment with10 ppm ozone gel with quenching after 3 h and treatment with 100-ppm ozone gel with immediate quenching showed antimicrobial effects in eight aerobic strains, namely, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Methicillin-resistant S. aureus(MRSA), S. epidermidis, Klebsiella pneumoniae, and Streptococcus mutans. For five of these strains (E. coli, P. aeruginosa, C. albicans, K. pneumoniae, and S. mutans), the number of colony forming units (CFUs) were below the detection limit after treatment with 10 ppm ozone gel with quenching after 3 h. For Bacillus subtilis, an antimicrobial effect was observed after 3 h of treatment with 100 ppm of ozone gel. In the case of anaerobic bacteria, bactericidal effect was observed for five strains, namely, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Eikenella corrodens, by using ozone gel and ozone cream. Of these, the number of CFUs for three strains (P. gingivalis, P. intermedia, and F. nucleatum) was below the detection limit. These results suggest that the ozone gel can be clinically useful in oral surgery for implant treatment because of its instantaneous antimicrobial effects, and that it can be used against a variety of bacterial strains.
