蛋白質導入法の開発とその医薬品開発への道

抄録

Protein transduction therapy with membrane-permeable peptide consisting of 10-20 amino acids is a recently developed methodology that is capable of delivering functional proteins, peptides, drugs, genes and so on into cells. Poly-arginine peptide and a basic peptide derived from the human immunodeficiency virus type 1 (HIV-1) are typical of the membrane-permeable peptide. Protein transduction therapy has received increasing attention as a novel and highly efficient technology to modify cellular functions with therapeutic potential; however, the therapy has some disadvantages such as the degeneration of delivered protein in endosomes/macropinosomes. The mechanism of protein transduction has recently been clarified, and this mechanism-based new approach was developed to overcome the disadvantages. In this symposium, I focus on the current understanding and therapeutic potential of protein transduction therapy.