［第70回日耳鼻総会シンポジウム:頭頸部悪性腫瘍における三者合併療法］上顎癌に対する動注療法について

抄録

Hydrogen peroxide and Mitomycin C infusion was employed in 38 cases of maxillary cancer for the purpose to increase the effect of anticancer agent. 4mg of MMC was injected in one shot after the infusion of Nyclin (40mg) and 0.12% H₂O₂. This procedure was continued for 10 days and partial resection of maxilla was made one week after the infusion. In the case of single infusion of MMC changes were seen in one week and in the case of hydrogen peroxide infusion in 3 to 4 days. Histological investigation revealed that degeneration was seen in tissue stroma in the case of one shot infusion and considerable degeneration was seen in all of the tumor tissue in the case of hydrogen peroxide infusion. These findings suggest that the hydrogen peroxide infusion intensify the effect of MMC. In this series injected hydrogen peroxide did not show any side reaction.