外リンパ腔内への低張液注入がCochlear Microphonicsに及ぼす影響

メニエール病の病態生理学的研究

抄録

In order to obtain some informations on the pathogenesis of Meniere's disease, the hypotonic solution (Aqua distillata) of 1.0 or 2.0 was injected into the scala tympani or scala vestibuli at the basal turn of guinea pigs and changes of cochlear microphonics were recorded at the basal turn and third turn simultaneously with the differential electrodes technique.
1. When the hypotonic solution was injected into either scala tympani or scala vestibuli at the basal turn, cochlear microphonics was affected only at the basal turn and there was no visible effect on cochlear microphonics at the third turn. This result seems to support the radial flow theory of the inner ear fluids.
2. As for the modification patterns of cochlear microphonics at the basal turn, there was a qualitative difference between the injection into the scala tympani and the injection into the scala vestibuli. When the hypotonic solution was injected into the scala tympani, cochlear microphonics, following a rapid decrease and recovery, showed a slow decrease and recovery. On the other hand by the injection into the scala vestibuli, cochlear microphonics showed only a slow decrease without recovery. From these results, it is presumed that the basilar membrane is easily permeable compared with the Reissner's membrane and then the production and absorption of perilymph are more active in the scala tympani than in the scala vestibuli.
3. The effects of the hypotonic solution on cochlear microphonics are quantitatively identical with the effects of the hypertonic solution injected into the perilymphatic spaces in spite of the inference that the hydrops of the cochlear duct should be induced by the injection of the hypotonic solution and the collapse of the cochlear duct by the hypertonic solution.
From the results obtained, it is presumed that changes of cochlear microphonics were caused by some direct osmotic effect of the hypertonic or hypotonic solution on the Corti's organ.