Application of the combined surgery, radiotherapy, and regional chemotherapy has made it possible to treat carcinomas of the nose and the paranasal sinuses without leaving any awkward defect in the face, and yet preserving the normal function. Thus, total resection of the maxilla has not been required even in advanced cases, since August, 1965. Besides, by this therapy the rate of local recurrences has been reduced and consequently, five year survival rate has been improved to more than 50 per cent.
At the sametime, however, the incidences of visual disturbances or bone necrosis increased gradually in the subsequent course. Before June, 1968, the patients were iufused with 5-Fluorouracil (5-FU) alone as a radiosensitizer. In this group, mean-total dosage of irradiation was 6000 rads. The incidences of complications were high in cases which were irradiated more than 7000 rads and infused more than 10 times. Since July, 1968, we added Bromodeoxyuridine (BUdR) to 5-FU. In the latter group, the average total dosage of irradiation and infusion decreased to 3000 rads and less than 10 times respectively, nevertheless, the rate of local recurrences also decreased and cosequently the number of patients who rehabilitated increased.