抄録
The therapeutic and preventive effects of Vitamin B1 for auditory impairment after the subcutaneous injection of quinine hydrochloride were observed by means of the microphonic response of the cochlear.
In these studies, Kittens of two or three months after birth were used as experimental animals and they were divided into four groups of experimental series. And the procedures for observing the response based upon cochlear potential were as follows: The maximum output, the intensity of the stimulating pure tone to produce 100 micro volts, and the equal loudness curve were measured for the forced vibration and the logarithmic decrement was measured for the free vibration with tuning forks.
The cats which were given daily injections of quinine hydrochloride alone subcutaneously showed an additional decrement of response.
When larger doses of Vitamin B1 were administered to the cats with auditory impairment due to quinine injection, a little improvement of the response was observed.
The radium therapy upon the cervical sympathetic ganglion of the cats with cochlear impairment was not as effective as the Vitamin B1 injection. When Vitamin B1 was injected simultaneously with quinine for a preventive purpose, they showed a favorable tendency to increase the response, for instance the decline of response of the group that had 10 injections of quinine together with Vitamin B1 was equal to that of the group that had two injections of quinine alone.
