抄録
Combination of Bleomycin and Mitomycin-C was effective against head and neck cancer. The therapeutic effects of the drugs are summarized as follows.
1) The drugs exert their effects rapidly on the tumors, causing necrotic changes of the neoplastic tissues.
2) The drugs reduce the metastatic mass of neck and relieve the distress in far advanced cases.
3) The antitumor effects of the drugs are enhanced by prior radiation therapy.
4) The therapeutic effect is most prominent against well differentiated type of squamous cell carcinoma, to which Bleomycin possesses specific affinity.
5) To maintain the effect of the both drugs, an additional drug is required: 5- Fluorouracil in dry syrup form is used for this purpose. Practical considerations are discussed in regard to host drug relationship.
