Two extirpated larynges with recurrence of supraglo0tttic cancer which had received Lineac irradiation in doses of 8000 rads in about one year and two years previously, and three larynges with squamous cell carcinoma that have been removed after preoperative Lineac therapy, receiving 3500-4500 rads in doses, were studied by a new technique of scanning electron microscopic cinematography.
Surface topography in squamous cell carcinoma of the larynx showed a bulging appearance of cell and an irregular rough pattern with an abundance of cytoplasmic process in different sizes and shapes, and looseness of each cell boundary.
In non-ciliated cells distributing in the false cord, entrance portion of ventricle and subglottic areas after Lineac radiation, significant changes of tightly packed microvilli and stripped or destructed cell surfaces were demonstrated.
Ciliated epithelium was also highly susceptible to irradiation.
Some evidences of compound cilia which caused in pathological adhesion of each cell membrane of the cilia, blebs formation and polypous appearance of the cilia with accompanying decreased numbers of cilia or shortness of ciliary shaft were presented characteristically.
From both morphological and functional points of view, radiation pathology of the laryngeal mucosa and cancer, in particular, practical significance in ultrastructural research on cinematographic analysis of SEM features were discussed briefly.
