Abstract
A clinico-pathological analysis is presented in a series of 60 patients with malignant lymphoma involving WALDEYER'S ring referred to Kagoshima University Hospital during recent 15 years period. This is the 37.3% of all malignant tumors at the same region. The anatomical distribution of the primary growth within WALDEYER'S ring was as follows: tonsil, 47 cases; epipharynx, 8cases; base of tongue, 5 cases. Male and female retio was approximately equal, and the age group of 50's and 60's were affected most commonly.
Grossly most of the tumors tended to have smooth surface with occational thin white plaque and expanding growth with less frequent ulceration than in squamous cell carcinoma.
The 5 year survival rate was 54.2% in 17 patients of clinical stage I, and 30% in 43 patients with metastasis. Applying RAPPAPORT'S classification, the relationship of histology and prognosis was evaluated. The survival rate of patients with nodular growth pattern (N=21) was better than the patients with diffuse pattern (N=39)(p<0.05). All 9 patients with lymphoblastic lympoma died within 24 months.
The surface marker of tumor cells was analyzed in 6 patients, resulting 4 cases with T-cell type and each one with B-cell and Null cell type. All T-cell lymphomas have a variable cytological feature.
