抄録
The ability of the nasal respiratory mucosa to clear themselves of accumulated foreign material and to provide an ever fresh and moist surface is essential to human health.
The purpose of the present study was to determine whether nasal clearance is affected by nasal spray with topical anesthetic and decongestant agents.
Nasal mucociliary flow rate was measured by saccharine technique.
Discoloration and shrinkage of the inferior turbinate was analysed using organ-reflectance spectrometry, and pathological change of the nasal mucosa was observed by scanning electron-microscope.
The excessive doses of topical anesthetic and vasocontrictor agents were found to cause functional and ultrastructial disturbences in the nasal mucosa.
A linear relationship was revealed among spectrometric value, coloriometric index, mucous flow rate and surface structural change in the mucous membrane of the nasal cavity.
On the basis of the results which have been thus obtained clinical evaluation of variable combination therapy with nasal spray was discussed briefly.
