抄録
I. A survey with questionaire.
Five-hundred and eleven ENT doctors responded to our questionaire. The most frequent office procedure was nebulizer (88%). Steroid and/or antibiotics were used most frequently. Many doctors believed that nebulizer was effective for acute laryngitis and post-surgical condition. Local application of medicines with the use of an applicator, a sprayer, an inhalator or a laryngeal syringe was less frequent. Intracordal injection of medicine was the least frequent.
II. Measurement of intra-tissue concentration of locally applied antibiotics.
Tobramycin concentration within the mucosa of canine vocal folds was measured. It was revealed that tobramycin applied on the mucosal surface was transported into the mucosa. Intracordal injection of tobramycin resulted in a very high intra-tissue concentration.
