上咽頭がんの治療について

抄録

We have treated and studied on 171 cases of nasopharyngeal cancer during 17 years, from 1962 to 1978. Among the subjects, 145 cases of carcinomata (85 %), 65 of lymphoepithelioma, 58 of squamous cell carcinoma, 18 of reticulum cell sarcoma and 10 of anaplastic carcinoma were included. The subiects in the upper 4 groups were radiosensitive. In the carcinomata, 63 % of the subjects were found to be in N3 stages.
Radiotherapy was performed on the primary and metastatic carcinoma, and surgery and/or regional chemotherapy were applied to the less radiologically reactive cases concomittantly.
Initial dose of radiation to the primary focus was 6,000 rad in average in 1960's, but it was minimized to as low as 2,700 rad after 1977. Surgery and/or regional chemotherapy were given concomittantly only when indicated.
The overall crude 5 year-survival ratio was 59 %. There was little difference between histopathological classification and T-classification, but they were found to be worse in the subjects of N3 stage (5 year-survival ratio, 48 %) than in NO, N1 and N2 stages (76 %). The death cause of the subjects having squamous cell carcinoma was due to progressed primary focus, but that of the subjects having lymphoepithelioma was due to distant metastasis.