Abstract
Bacteriological investigation of the aural discharge in 144 cases of chronic suppurative otitis media from patients who visited our clinic from July 1980 to June 1981 was performed.
Ten ears were treated with KW-1070 (Fortimicin) and its effect was clinically evaluated.
The following conclusions were obtained.
1. Two hundred and twelve cultures were isolated from the 144 specimens. There were gram-positive cocci (51.9%), gram-positive bacilli (11.8%), and gram-negative bacilli (35.4%).
2. KW-1070 was administered to 8 cases (10 ears) with severe chronic otitis media. The clinical efficacy of KW-1070, as measured by diminished ear discharge, was 50%.
3. Bacteriologically, 12 of 20 different species of bacteria disappeared after treatment with KW-1070, however, 8 organisms were still cultured. The bacteriological efficiency of KW-1070, thus is 60%.
4. KW-1070 was significantly effective in one case which showed no sensitivity to AMK.
5. No serious side effects were observed, including hepatic, renal or auditory complication, except one case which showed a small and transient increase in GOT and GPT.
