Abstract
Investigations of a new antibiotic, fosfomycin, were conducted. Concentrations in blood and tissues were studied 1 and 2 hours after administration of either capsule or dry syrup fosfomycin.
Two hours after administration of 2g of the dry syrup, the maximum concentration in blood was 8.31μg/ml, 4.51μg/g in palatine tonsil, 3.92μg in the mucous membrane of the maxillary sinus, 3.18μg/ml in maxillary exudate, 5.26μg/g in nasal polyp, 2.72μ/g in inferior turbinates, and 1.94μg/g in the nasal tumor tissue. No measurable concentration was found in exudate of maxillary cyst.
One hour after administration of 1g of syrup, the maximum blood concentration was 5.57μg/ml.
Two hours after administration of a 2g capsule, the concentration was 7.05μg/ml.
