抄録
The morphological changes of nasal mucosa after nasal spray with drugs such as decongestants, anesthetics, lysozyme chloride, beclomethasone dipropionate and physiolosical saline solution were examined with scanning electron microscopy in human subjects and in guinea pigs. In a clinical study, 18 cases were investigated. The first group of cases composed of 11 with hypertrophic rhinitis and 5 with nasal allergy, were sprayed with a decongestant and anesthetic solution on one side of the nasal cavity for three to fourteen days before nasal operation undertaken. As a control, the other side was sprayed with only physiolosical saline solution. In two additional cases with nasal allergy, the nasal cavities were sprayed bilaterally with beclomethasone dipropionate for three days in one case and for over a month in the other. The specimens which were taken bilaterally by turbinectomies were observed by means of scanning electron microscopy. The characteristic changes of mucosal surface, such as squamous cell metaplasia, bulging of the, cell surface, swelling of microvilli, acceleration of secretion and cell destruction, were more marked in the drug-sprayed specimens compared with the control specimens. In an experimental study, 25 guinea pigs were divided into 5 groups and sprayed intranasally for fourteen days with decongestant, anesthetic, lysozyme chloride, beclomethasone dipropionate and physiological saline solution, respectively. The morphological characteristics of the nasal mucosa were indistinctness of the cell border, swelling of the cell surface and destruction of cell membrane with some ciliary damage. These morphological changes were most marked in the decongestant group followed by the anesthetic group. Little change was found in either the lysozyme group or the beclomethasone group. Topical treatments of the nose were evaluated and their clinical significance was discussed briefly.
