抄録
It has been clinically recognized that the labyrinthine functions are probably influenced by local blood pressure surrounding there. Recently, Prof. Kawata (1951) reported that the irradiation to the superior cervical sympathetic ganglion was very effective to the nervedeafness (Nerven schwerhörigkeit) and he explained the mechanism of this effect from the standpoint of autonomic nervous function.
Using eight ears of the conditioned four dogs of normal hearing, the effects of autonomic drugs, antihistamine preparation, anticholine preparation, and hormons of circulatory system upon the hearing were investigated by the aid of objective audiometry with conditioning response, and at that time the suitable dose of drugs for injection was calculated from the experiments in the human body.
The augmentation of hearing was observed in the injection of Kalliklein, Newrogirt and Imydalin, and especially all ears of cases to which Kalliklein was injected revealed the temporary lowering of threshold.(Some cases showed the augmentation of hearing as about 20 db.)
The drugs as Bosmin, Adopon, and Benapon acted to decrease the hearing. Above all when Bosmin was injected all ears showed the temporary increasing of threshold namely the temporary decreasing of hearing which was amounted to 15 db.
Ryegostine which was ergot preparation gave no typical results.
From the data described above the authors concluded that the changes of hearing when various drugs were applied were presumably produced by the temporary change of labyrinthine blood vessel and hence blood stream.
