抄録
The distribution of aspoxicillin (ASPC: TA-058) and sulbenicillin (SBPC) into middle ear effusion and petrosal mucous membrane was studied in experimental otitis media in guinea pig infected with Streptococcus pneumoniae. ASPC and SBPC were administered at a dose of 40mg per kg or 100mg per kg of body weight by intravenous or intramuscular injection. ASPC reached higher level both in the middle ear effusion and the petrosal mucous membrane at its peak than SBPC, and the level was higher than SBPC at every time in every dose. ASPC had a longer term to surpass MIC's 75 than SBPC against various clinical isolates including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Bacteroides fragilis.
