Abstract
The ototoxicity of antiseptics applied in the middle ear cavity of the guinea pig was studied. Inner ear dysfunction was evaluated with recording endocochlear dc potential (EP) and cochlear microphonics (CM). Hibitane gluconate solution 0.5% damaged the inner ear within 30 minutes after application. Hibitane gluconate solution 0.02% and Isodine 10% solution did not make any significant changes on EP and CM within 30 minutes. Hibitane gluconate solution 0.02% and Isodine 10% solution showed a significant sterilizing effect within a few minutes. These antiseptics can be used, if their concentration and application time are carefully controlled.
