服部浩教授退官記念論文 頭頸部扁平上皮癌患者における血中SCC抗原

抄録

SCC antigen was purified from human liver metastatic lesion of uterine cervical squamous cell carcinoma. We determined the serum SCC antigen levels in patients with head and neck squamous cell carcinomas by double-antibody radioimmunoassay method. Twelve of 18 pretreatment patients (66.7%) showed elevated serum SCC antigen levels. The serum antigen levels were decreased in most cases, by treatments, such as surgery, irradiation and chemotherapy. Antigen levels tended to increase by recurrence or metastasis. Our studies indicate that serum SCC antigen levels are clinically useful for monitoring the response to treatment in patients with head and neck squamous cell carcinomas.