Pathogenesis of the polypoid vocal fold was investigated by clinicostatistical, histological and chemical analyses. Results from the clinical study indicated that long term smoking was one of the most causative factors in the development of the polypoid vocal fold. Moreover, fibrous tissue weakness and decreases in various chemical substances in the mucosa of the vocal fold due to aging appeared to break down the blood vessels in the mucosa during phonation. Under these conditions, the acid glycoprotein from the serum oozes out little by little into the superficial layer of the vocal fold and becomes a concentrated mucoid substance. In mild cases of the polypoid vocal fold, conservative treatment is recommended initially. Otherwise, surgical treatment shoud be performed. Regarding vocal improvement after complete healing of surgery, there was no significant difference between the stripping technique and the sucking technique. However, in terms of immediate postoperative vocal usage, the sucking technique is more advantageous than the stripping technique.