抄録
The auditory brain stem response can be used not only as a diagnostic tool in audiological disorders but also as a functional test of brain activity in comatose patients, where a variety of pathological and physiological conditions is found. In the present paper, the effects of blood pressure, blood respiratory gas level and rectal temperature on auditory brainstem response in guinea pig were investigated. When the mean blood pressure dropped 32.9% from the value of control, there were no change in the ABR. The ABR was not affected by a high oxygen partial pressure in the artery in any case of normothermic, hypothermic and after rewarming condition. Systemic cooling, induced with chlorpromazine and an ice bag, prolonged the latencies and reduced the amplitude of waves I to IV. The rectal temperature was manipulated from 37° to 27°. The data indicated that a reduction of 1° in rectal temperature was associated with an increase of 5.9% in the interval between waves I to IV. Body temperature should be controlled in interpreting both experimental and clinical ABR recordings.
