Abstract
Eosinophilic granuloma of the bone is a rare benign disease which is characterized by osteolytic lesions. The disease often affects children or adolescents, frequently at the site of the temporal bone. A 38-year-old male with eosinophilic granuloma of the right temporal bone is reported. The patient complained of persistent otorrhea and hearing loss. Granulous tissue was observed in the right external ear canal and upon X-ray examination a wide osteolytic lesion of the right temporal bone was described. A mastoidectomy was performed and histological examination of the mastoid tissue revealed granulation. Subsequently, as confirmed by the clinical course and positive staining of S-100 protein in the histiocytes, a diagnosis of eosinophilic granuloma of bone was established. Following surgery, an osteolytic lesion of the right pelvic bone was also demonstrated. Irradiation and chemotherapy with steroid and cyclophosphamide were administered. Following radiation doses of 15.4Gy to the right temporal bone and 16Gy to the right pelvic bone, a combination of methylprednisolone and cyclophospamide were used. Otorrhea diminished gradu ally, and clinical remission followed. Laboratory data such as ESR and CRP also returned to normal following irradiation and chemotherapy.
