Abstract
A 74-year-old female with malignant melanoma of the nasal cavity and no metastasis was treated with combination therapy consisting of local injections of interferon-β and radiotherapy. The treatment resulted in a remarkable decrease in the size of the tumor. After 15 intranasal injections of interferon-β, the nasal cavity tumor completely disappeared. She had no serious side effects during the treatment. Although local recurrence occurred one month after the initial treatment, it disappeared after local injections of interferon-β. The patient has demonstrated no recurrence for 2 years after the initial treatment. Taking the patient's quality of life into consideration, the combination therapy which we used is therefore considered to be useful for the treatment of malignant melanoma. In addition, local injections of interferon-β are also considered useful for the control of local recurrence.
