Abstract
The efficacy of combination therapy consisting of anti-histamine and anti-leukotriene drugs was compared with the monotherapy of each drug for Japanese Cedar Pollinosis patients. Fifty-one patients were randomized into 3 groups: cetirizine 10mg once a day, planlukast 225mg twice a day, or the combination of both, for more than 6 weeks during the pollen season of 2000. The symptom score, medication score and the symptom-medication score were calculated based on the daily symptoms which the patients recorded in diaries. The nasal symptoms improved in all groups, but no synergic effect of the combination therapy was observed in this study. Additional studies are required to confirm the usefulness of this combination therapy using anti-histamine and anti-leukotriene drugs for the treatment of seasonal allergic rhinitis.
