Abstract
We report the results of superselective intraarterial CDDP infusion and concomitant radiotherapy for 25 patients with stage IV oropharyngeal carcionamas, compared with 52 patients treated before introduction of intraarterial chemoradiation. The 5-year cause-specific survival rates in the intraarterial chemoradiation group were 89% for under T2, 58% for T4 and 72% for total patients, including 2 patients with T3 who are alive within 5 years after treatment. On the other hand, the survival rates in the past group were 75% for T2, 50% for T3, 39% for T4 and 48% in all. The survival rates of the operated patients in the past group were 75% for T2 and T3, 50% for T4, but 31 of 34 patients in this group had extensive resection required reconstruction surgery. However, only 6 patients received partial resection in the intraarteial chemoradiation group. We conclude that intraarterial CDDP infusion combined with radiotherapy is very effective for patients with advanced oropharyngeal carcinomas, because it makes minimizing dysfunction and possibly improving survival.
