Disodium Cromoglycateの鼻粘膜好塩基性細胞に対する効果

抄録

In order to elucidate the characteristic of two different kinds of nasal mast cells, i.e., mucosal mast cells (MMC) and connective tissue mast cells (CTMC), we examined the inhibitory effect of disodium cromoglycate (DSCG) on the allergen induced histamine release from nasal mast cells in 75 patients with the house dust nasal allergy. Pharyngeal mast cells were also examined as a control.
After incubation of nasal scrapings, pieces of chopped nasal mucosae without epithelial layer or chopped pharyngeal mucosae with house dust extract alone or mixture of house dust and DSCG solution (30uM, 150uM, 750uM), we measured the percentage of histamine release and the percentage inhibition of histamine release of DSCG.
As results, nasal scrapings were less sensitive to DSCG, and both the chopped nasal mucosas without epithelial layer and chopped pharyngeal mucosas were very sensitive to DSCG.
These results clearly indicate that DSCG is non-effective on nasal surface basophilic cells (NSBC), whereas effective on the lamina propria mast cells of the nasal as well as the pharyngeal mucosa. These indicate that there are two distinct types of mast cells in the allergic nasal mucosa. NSBC is similar to MMC and lamina propria mast cells of nasal mucosa are similar to CTMC in response to DSCG.