Massive dosage alinamin F (thiamine tetrahydrof uryl sulfide) therapy (150mg/day) was performed on 267 ears suffering from various type of perceptive deafness. Therapeutic effect was found in 34.5% of the series. It must be emphasized that the earlier the patient began to undergo this treatment, the more favorable result was obtained. 79.2% of the patients who began to undergo the treatmant within one week from the onset of the disease proved effective, and in the cases that were treated within one month from the beginning of deafness 74.3% benefited from the treatment. To our regret, nearly half of the series had began to undergo the treatment in more than half years from the onset of deafness with satisfactory result only in less than 30% of them.
The therapeutic effect was most markedly observed when the treatment was continued during two or three months.
