抄録
The efficacy and tolerability of diclofenac sodium suppositories administered 25mg b. i. d. for 5 days to children with post-tonsillectomy pain and inflammation were investigated in a well-controlled study of 40 patients comparing it with the treatment with a non-diclofenac sodium drug. In this trial, diclofenac sodium showed quick onset of analgestic action and was superior to the treatment with a non-diclofenac sodium drug in the analgestic and anti-inflammatory effect after 3 days. There was no difference in efficacy between 2 treatments after 5 days.
Laboratory tests (hematology, serum biochemistry and urinalysis) were normal, and mild vomiting was reported for diclofenac sodium. Plasma concentrations of diclofenac were measured following a single dose of diclofenac sodium 25mg in 5 children.
No difference was observed in the peak plasma concentrations (C Max) or time to reach the peak concentration (t Max) between diclofenac sodium 25mg in children and diclofenac sodium 50mg in adults.
