抄録
The level of cefuzonam (CZON) in otorrhea discharge was measured to evaluate the clinical effectiveness of this drug in the treatment of middle ear infection. The concentration of CZON ranged from 1, μg/g to 2μg/g for 4 hours after 1g single i. v. injection (SIV), 2μg /g to 6μg/g for 3 hours after 2g SIV, 1μg/g to 2μg/g for 2 hours after 1g i. v. drip infusion (IVD) over 30 minutes, and 2μg/g to 5μg/g for 2 hours after 2g IVD over 30 minutes. In the cases of chronic otitis media including cholesteatoma, the most commonly isolated bacteria were Staphylococcus aureus (25.6%) and Pseudomonas aeruginosa (25.6%), followed by Staphylococcus epidermidis (8.5%). In the literature, the MICgo of CZON is reported to be ≤ 1.56μg/ml for Staphylococcus aureus
except MRSA and 6.25μg/ml for Staphylococcus epidermidis. CZON is effective against all these bacteria except Pseudomonas aeruginoa.
