Single photone mission computed tomography (SPECT) with intra-arterial perfusion of 99mTc-macroaggregated albumin (MAA) was used to examine four patients with head and neck cancer. This method was much more accurate in determining the perfusion area of tumors deep in the head and neck than the conventional dye method, Tc-MAA planar method, or arterial angiography. A comparison of Tc+Tc-MAA SPECT with Tc SPECT was the most useful way of identifying the perfusion area. This method also seemed to be useful in the assessment of the effect of intra-arterial perfusion therapy.
