Two cases of Pierre Robin sequence are reported. The Pierre Robin sequence is a grouping of abnormalities that includes micrognathia, glossoptosis, upper airway obstruction, and cleft palate. It is suggested that micrognathia is the primary anormaly that causes glossoptosis, upper airway obstruction, and cleft palate, and that mandibular abnormality may have many different causes. The etiology is complex, and it has been suggested that it may be a nonspecific symptom complex rather than a specific syndrome. Problems in the postoperative course are the same as those in the neonatal period; children with the Pierre Robin sequence may present with respiratory obstruction and feeding difficulties shortly after birth and operation. The management of this condition includes prone positioning, tongue traction, glossopexy, nasopharyngeal tubes, intubation, and tracheostomy. The obstruction in our cases was well controlled with prone positioning.