Pleomorphic adenomas in several salivary glands are rare. We report a patient with pleomorphic adenomas in the right parotid gland and the left submandibular gland. Preoperative MRI and neck echography revealed masses in the right parotid gland and the left submandibular gland. Right superficial parotidectomy and left submandibular sialoadenectomy were performed and the histopathologic diagnosis was Pleomorphic adenoma, with no suggestion of malignancy and metastasis. To our knowledge, there have been no previous reports of pleomorphic adenoma both in the parotid gland and in the submandibular gland of the other side.