Abstract
Thirty-nine cases of nasal and paranasal papilloma treated in Tenri Hospital during the last 20 years were reviewed. In 6 cases (15%), squamous cell carcinoma was accompanied by papilloma and all were inverted papilloma. Two were male and 4 were female. The mean patient age in these 6 malignant cases was 73 years old, which was 13 years older than that in benign cases. In the 6 malignant cases, the lesions tended to be more extensive and more often involved the frontal sinus or sphenoid sinus than lesions in benign cases. Clinical symptoms and bone destruction in radiographic studies did not clearly characterize the existence of malignancy.
Three cases were preoperatively diagnosed as carcinoma and were treated with a combination of surgery, irradiation and chemotherapy. The other cases were diagnosed as carcinoma from surgically obtained materials and two received postoperative radiotherapy while one case did not. The 3-year survival rate was 80%.
