Gut Microbiota and T_H1, T_H2, CD8⁺ T Cell Immune Responses

Abstract

T cells play a critical ro" in antigen-specific immune responses and their differentiation and function are affected by gut microbiota. αβ TCR expressing T cells are basically divided into CD4⁺ and CD8⁺ T cells. Among CD4⁺ T cells, T_H1 cells contribute to the c"arance of pathogen infections and their activation may cause development or exacerbation of autoimmune diseases. T_H2 cells serve as the main effector against helminth infection and also cause al"rgic reactions. CD8⁺ T cells play an important ro" in immunity against pathogens and cancers. In this review, we introduce intestinal bacteria that can affect the T_H1/ T_H2/CD8⁺ T cells-mediated immune response and diseases.