Abstract
Poorly designed observational study often produces results difficult to interpret. Researcher should minimize the measurement error and confounding to make research findings meaningful. The STROBE statement (Strengthening the Reporting of OBservation studies in Epidemiology statement), the reporting guideline for observational study, is useful in designing research carefully. This issue aimed at explanation 5 critical points to design observational study according to the STROBE statement (i.e., clearly defined purpose, explanation of the scientific background and rationale for the research, sample size calculations, precise details of measurement, and confounder), and providing detailed examples from published papers for each.
