ラット門脈カテーテル留置法によるキサンタンガムと 医薬品の相互作用の検討

抄録

Xanthan gum is used as a major ingredient in thickened food products served in various medical and welfare facilities. However, drug absorption may be affected when xanthan gum is consumed with the drug. In the present study, we therefore investigated the effects of xanthan gum on drug absorption using rat portal vein catheterization. Rats were given single doses of ibuprofen (75 mg/kg), acetylsalicylic acid (75 mg/kg), acetaminophen (100 mg/kg), and metformin hydrochloride (50 mg/kg) directly into the stomach while being continuously administered a 0.1% aqueous solution of xanthan gum. Blood concentrations immediately after administration of each drug were lower than in the control group, as drug absorption in the gastrointestinal tract was suppressed by xanthan gum. On the other hand, although ibuprofen blood concentrations immediately after administration were lower than in controls, subsequent levels were higher than in the control group. Moreover, the area under the curve (AUC) of ibuprofen blood concentrations was significantly higher than in the control group. Based on these findings, it was clear that xanthan gum inhibits drug absorption immediately after administration and reduces peak blood concentrations. Moreover, for ibuprofen, although the peak blood concentrations were lower, subsequent blood concentrations were maintained at higher levels, and higher quantities of the drug were absorbed.