Abstract
The use of sweeteners has been on the rise due to health consciousness in recent years. The simultaneous sweetener analysis with a dialysis method and LC-MS/MS is easy to process multiple samples for a large number of processed foods in Japan and overseas. The validation guidelines provided in March 2024 make reliability in food additive analysis important. Since there are few reports of intermediate precision in sweetener analysis with the dialysis method, this study reported the internal quality control method that was applied to the past results. The results fulfilled the standard values set in the validity evaluation guidelines of 70 - 120% recovery rate, less than 10% repeatability, and less than 15% intermediate precision.
