Evaluation of the stability and biological delivery properties of ceramide emulsions prepared with soybean lysolecithin

Abstract

Soybean lecithin is known as a naturally derived emulsifier and has been widely utilized in various fields such as food, pharmaceuticals, and cosmetics. In this study, we investigated the physicochemical stability and intestinal delivery of corn ceramide emulsions prepared with enzyme-hydrolyzed soybean lecithin (SLP-lyso), compared to those prepared using non-hydrolyzed soybean lecithin (SLP). The SLP-lyso emulsions exhibited smaller and more uniform particle sizes and maintained excellent stability even under strongly acidic conditions (pH 1.2). This stability is likely due to the enhanced hydrophilicity and interfacial activity of lysolecithin. Furthermore, in an artificial intestinal membrane model, SLP-lyso emulsions suggested greater membrane adsorption than SLP emulsions. These findings suggest that lysolecithin-based ceramide emulsions could improve oral delivery through enhanced stability and intestinal adsorption upon oral administration.