Abstract
A 51-year-old woman was referred to our hospital with a liver tumor detected by abdominal screening. Computed tomography demonstrated a low-density area located in segments 4 and 8 of the liver, and its peripheral area was stained strongly in the early phase and slightly in the late phase, while the central part was not enhanced in the both phases. With a diagnosis of intrahepatic cholangiocarcinoma (ICC) or combined type hepatocellular carcinoma, left medial sectionectomy and segment 8 segmentectomy of the liver was performed. On pathological examination, there were two components of cell differentiation. In the peripheral areas of the tumor, histological features corresponded to the bile duct adenoma (BDA). In the central component, the feature corresponded to the ICC. There was a transition between the BDA and ICC. p53-immunostaining was performed. The nuclei of the BDA component were stained less than those of the ICC component. The present case shows an ICC that developed in a BDA, which may indicate that there is an adenoma-carcinoma-sequence in ICC.
