有機鉛化合物の吸収および排泄に関する研究

その1. 四エチル鉛の吸収および排泄について

抄録

The relationships on absorption and excretion of tetraethyllead and lead acetate were studied in rabbits.
These compounds were given 30mg (as lead) per day by subcutaneous injection ten times every other day, and the transition of lead concenrtations in blood, urine and feces, hematological finding and coproporphyrin in urine were examined.
After the duration of 7∼9 weeks, rabbits were killed and the lead concentrations in tissues were also determined.
It was found that,
1) the increases of lead concentrations in blood were not so remarkable in the group which were given tetraethyllead as which were given lead acetate,
2) those in urine were almost equivalent between two groups,
3) those in feces were more rapidly and remarkable in the former group than in the latter group,
4) although in tissues, generally, marked amounts of lead were accumulated in liver and kidney, those distributions were different from both groups, and in the former group there were more in liver, muscle and brain than in latter group,
5) and the amounts of coproporphyrine in urine were lower in the former group than in the latter group.