Abstract
After oral or intravenous administration of 14C-dibutyl phthalate into male mice, radioactivity was found to be rapidly distributed in the organs and tissues by whole body autoradiography. In particular, a high level of radioactivity was found in the liver and kidneys within the first hour after intravenous injection of 14C-DBP and rapidly decreased thereafter. In these male mice, the urine and feces level of radioactivity after intravenous injection of 14C-DBP reached a peak at 30min and 1hr, respectively, and then declined rapidly. However, the feces level of radioactivity after oral administration of 14C-DBP reached a peak at 6hr and then decreased gradually.
From the above results, it was suggested that orally or intravenously administered 14C-DBP into male mice was readily absorbed from the gastrointestinal tract and rapidly excreted in the urine and feces.
