Flow pattern and axial pressure loss are investigated experimentally for gas-liquid (air-water) two-phase flow when the flow passes through a rotating pipe. It is observed that as a result of the rotation bubbles are gathered toward the center of the rotating pipe while the liquid is pushed to the pipe wall covering a large area of the pipe wall. The pressure loss along the span of the rotating pipe decreases when the rotation speed is increased. A correlation for the two-phase friction multiplication factor derived from the experimental observations including the effect of the pipe rotation is proposed, estimating the experimental data reasonably within the range of this experiment.