Retinoblastoma is a malignant tumor originally derived from the immature retina in infancy and childhood. It usually occurs in patients younger than 2 years. Although the prognosis after treatment is relatively good, the prognosis becomes poor if extraocular extension, distant metastases, or both occur. A 1 and a half-year-old male had been given a diagnosis of a retinoblastoma of the left eye and received conservative treatment. A recurrent tumor was later found, and metastatic tumors were detected in the bone marrow, femur, and mandible 6 months later. Chemotherapy was performed at that time. Thereafter, enucleation of the left eye and peripheral blood stem-cell transplantation with ultra-high-dose chemotherapy were performed. Consequently, cerebrospinal irradiation was also performed. The patient has been in remission for 6 years. The mandible has no findings of recurrence and no dysgenesis. The permanent teeth have nearly all erupted with short roots and provide good occlusion.
