We describe a case of sialolithiasis of the buccal mucosa with a fungal mass in a calculus of the minor salivary gland. An 87-year-old man was referred to our hospital because of a small nodule in the right buccal mucosa. On examination, an elastic, hard, painless, movable nodule, measuring 3 × 3 mm and located under the right buccal mucosa, was detected. The overlying mucosal surface was intact. Radiographic examination revealed no abnormalities in the right buccal region. We resected the nodule with the patient under local anesthesia. Histological examination of the resected specimen revealed lightly eosinophilic material with lamellar calcification and colonies of yeast-like fungus in a duct of the minor salivary gland. Comparative 26S ribosomal DNA sequence analysis of paraffin sections identified the fungus as Candida parapsilosis. This case suggests a potential role of mycosis in the etiopathogenesis of sialolithiasis.
